Which statin exhibits no risk for drug-food interaction with grapefruit juice?

Rosuvastatin is the statin that exhibits no significant risk for drug-food interaction with grapefruit juice. This is primarily due to its pharmacokinetic profile. Unlike other statins, rosuvastatin is not significantly metabolized by the cytochrome P450 3A4 enzyme system, which is the pathway through which many statins, such as atorvastatin, simvastatin, and lovastatin, are affected by grapefruit juice. Grapefruit juice can inhibit this enzyme, potentially leading to higher concentrations of those statins in the bloodstream, which increases the risk of side effects, particularly muscle-related issues and liver enzyme elevation. Therefore, rosuvastatin can be considered safe for patients who consume grapefruit juice, making it a suitable option when dietary restrictions are a concern.