Which of the following is NOT a typical symptom of anemia of chronic disease?

Anemia of chronic disease is often characterized by symptoms that arise from insufficient red blood cell production or shortened lifespan of red blood cells, typically due to underlying conditions such as infections, autoimmune disorders, or malignancies. Common symptoms associated with this type of anemia include fatigue, shortness of breath, and lightheadedness, as they result from reduced oxygen-carrying capacity of the blood leading to decreased tissue oxygenation.

Menstrual irregularities, while they can occur in various types of anemias, are not considered a typical symptom of anemia of chronic disease. This condition primarily affects individuals with chronic inflammatory states, and while menstrual issues may arise from other forms of anemia or underlying health problems, they are not a direct consequence of anemia of chronic disease itself. Therefore, menstrual irregularities stand out as the option that is least likely to be connected with this specific type of anemia.