Which medication can interfere with the effectiveness of an ACE inhibitor?

The reason ibuprofen is the correct answer is that nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can reduce the effectiveness of ACE inhibitors. ACE inhibitors work by promoting vasodilation and reducing blood pressure through the inhibition of angiotensin-converting enzyme. However, NSAIDs can cause sodium retention, increase blood pressure, and lead to kidney dysfunction, which opposes the effects of ACE inhibitors.

In contrast, clopidogrel is an antiplatelet medication and does not have a direct interaction with ACE inhibitors that would diminish their effectiveness. Atorvastatin is a cholesterol-lowering medication that also does not interfere with the function of ACE inhibitors. Acetaminophen, primarily used for pain relief, does not have the same potential effects on renal function or blood pressure regulation as NSAIDs do.

Therefore, the interaction between ibuprofen and ACE inhibitors makes it the most relevant choice in this context.