Which laboratory result is commonly associated with alcohol abuse?

Macrocytosis is commonly associated with alcohol abuse due to the effects of alcohol on the bone marrow and its interference with the absorption of certain nutrients, particularly vitamin B12 and folate. Chronic alcohol consumption can lead to a deficiency in these nutrients, which are essential for red blood cell production and DNA synthesis. As a result, the production of larger than normal red blood cells (macrocytes) occurs, leading to macrocytosis.

This association is particularly relevant because macrocytosis may be one of the first hematological changes noted in individuals with alcohol use disorders. Recognizing macrocytosis in patients can serve as a potential indicator of alcohol misuse, prompting further evaluation and intervention.