What type of diabetes is primarily associated with insulin resistance?

Type 2 diabetes mellitus is primarily associated with insulin resistance, which is a condition where the body's cells become less responsive to the hormone insulin. This resistance leads to higher levels of glucose in the bloodstream because insulin's ability to facilitate glucose uptake into cells is diminished. In addition to insulin resistance, Type 2 diabetes often involves an eventual decline in insulin production by the pancreas as the disease progresses.

In this condition, the body's insulin may be present but cannot effectively lower blood glucose levels due to the cells' resistance to the hormone's action. Type 2 diabetes is often linked to factors such as obesity, physical inactivity, and genetic predisposition. The management of Type 2 diabetes typically involves lifestyle modifications, pharmacological treatments that increase insulin sensitivity, and sometimes insulin therapy as the disease advances.

While other forms of diabetes, such as Type 1 diabetes, gestational diabetes, and pre-diabetes, also involve glucose metabolism, they do not primarily hinge on the mechanism of insulin resistance as central to their pathophysiology.