What is considered the leading cause of heart disease in the United States?

Atherosclerosis is identified as the leading cause of heart disease in the United States because it is the underlying condition that leads to many cardiovascular events. This process involves the buildup of fatty deposits, cholesterol, and other substances in the arterial walls, which narrows blood vessels and reduces blood flow. As a result, atherosclerosis significantly increases the risk of heart attacks, strokes, and other serious cardiovascular problems.

While hypertension, diabetes, and obesity are all significant risk factors for heart disease, they often contribute to the development of atherosclerosis. For instance, high blood pressure can damage arteries, making them more susceptible to plaque buildup. Similarly, diabetes can lead to increased levels of glucose in the blood, which can accelerate atherosclerosis. Obesity is associated with various metabolic conditions that further exacerbate the risk of atherosclerosis. However, none of these conditions directly represent the primary pathological process leading to heart disease in the majority of cases, which is why atherosclerosis is recognized as the leading cause.