What common side effect is associated with ACE inhibitors?

One of the most common side effects associated with ACE inhibitors is a persistent dry cough. This occurs due to the accumulation of bradykinin, a peptide that can increase in concentration when ACE is inhibited. Bradykinin is known to irritate the respiratory tract and lead to a cough reflex in some patients. While the cough is generally not dangerous, it can be bothersome enough that some individuals may need to discontinue the medication.

The phenomenon can vary in intensity among individuals, and it's important for healthcare providers to counsel patients about this potential side effect when prescribing ACE inhibitors. Monitoring for this reaction is part of effective patient management while utilizing these medications for conditions such as hypertension and heart failure.