For which condition is the use of oral decongestants least appropriate?

Oral decongestants, such as pseudoephedrine, are effective in relieving nasal congestion by constricting blood vessels in the nasal passages. However, in patients with hypertension, the use of these medications is least appropriate due to their potential to elevate blood pressure. The mechanism by which oral decongestants exert their effect can lead to increased sympathetic nervous system activity, resulting in vasoconstriction that may exacerbate existing hypertension or complicate its management.

With hypertension as a primary condition, practitioners often seek alternative treatments for nasal congestion that do not increase blood pressure. Other options for treating conditions like allergic rhinitis, the common cold, or Eustachian tube dysfunction may not pose the same risk and can safely utilize oral decongestants when warranted. Therefore, the association between oral decongestants and potential adverse cardiovascular effects makes them least suitable for individuals with hypertension.