For which condition is cyproheptadine (Periactin®) most appropriately indicated?

Cyproheptadine is an antihistamine with notable appetite-stimulating properties, making it particularly useful in clinical scenarios where increasing appetite is a primary goal. In the case of a 21-year-old with anorexia nervosa, this medication may be indicated to help stimulate appetite and promote weight gain in patients who are struggling with food intake due to psychological factors.

In anorexia nervosa, individuals often have a distorted body image and may refuse to eat, leading to severe weight loss and malnutrition. Cyproheptadine can be useful in these situations as it helps to counteract these appetite suppressing effects. It is essential to use this medication as part of a broader treatment plan, which may include psychotherapy and nutritional support.

The other options represent conditions where cyproheptadine would not address the primary concerns adequately. For instance, in binge-eating disorder, psychological interventions and behavioral modifications are more critical. In cases of acute gastroenteritis, the focus is on rehydration and electrolyte replacement rather than appetite stimulation. Similarly, type 2 diabetes management focuses primarily on glucose control and lifestyle changes, not on appetite enhancement. Thus, the use of cyproheptadine is most appropriate in the context of anorexia nervosa